Speaker: Academician Nikhil R. Pal
Title: Computational Intelligence for the discovery of biomarkers including synergistic markers for diseases
Time: 9:30am, August 23th, 2023 (Wednesday)
Location: 290 Arts and Science Building
Abstract:
In this talk we shall very briefly discuss Computational Intelligence, its relation to artificial intelligence and how it can help bio-medicine/healthcare. In this context, we shall discuss how bio-markers for different cancers can be discovered using computational intelligence techniques. In this regard, we shall gene expression data. There can be at least two kinds of bio-markers. In the first case, each gene in its own merit exhibits good discriminative power, while in the other case each gene (of a set) in its own merit is not a good marker (does not have good discriminative power), but when used together the set exhibits synergistic behaveior with respect to the disease. The first kind of genes will be discovered using neural network and fuzzy sets theory together, while the second kind will be identified using a very simple yet innovative fuzzy rue-based systems. In both cases, we shall find human understandable rules, which are very important for bio-medical applications. We shall illustrate identification of the two kinds of markers using two different datasets on cancers, namely Small Round Blue Cell Tumor (SRBCT) dataset on four childhood cancers and a prostrate cancer data set.
Personal Introduction:
Nikhil R. Pal is a Professor in the Electronics and Communication Sciences Unit and is the Head of the Center for Artificial Intelligence and Machine Learning of the Indian Statistical Institute. His current research interest includes brain science, computational intelligence, machine learning and data mining. He was the Editor-in-Chief of the IEEE Transactions on Fuzzy Systems for the period January 2005-December 2010. He has served/been serving on the editorial /advisory board/ steering committee of several journals including the International Journal of Approximate Reasoning, Applied Soft Computing, International Journal of Neural Systems, Fuzzy Sets and Systems, IEEE Transactions on Fuzzy Systems and the IEEE Transactions on Cybernetics. He is a recipient of the 2015 IEEE Computational Intelligence Society (CIS) Fuzzy Systems Pioneer Award and 2021 IEEE CIS Meritorious Service Award. He has given many plenary/keynote speeches in different premier international conferences in the area of computational intelligence. He has served as the General Chair, Program Chair, and co-Program chair of several conferences. He has been a Distinguished Lecturer of the IEEE CIS (2010-2012, 2016-2018, 2022-2024) and was a member of the Administrative Committee of the IEEE CIS (2010-2012). He has served as the Vice-President for Publications of the IEEE CIS (2013-2016) and the President of the IEEE CIS (2018-2019). He is a Fellow of the West Bengal Academy of Science and Technology, Institution of Electronics and Tele Communication Engineers, National Academy of Sciences, India, Indian National Academy of Engineering, Indian National Science Academy, International Fuzzy Systems Association (IFSA), The World Academy of Sciences, and a Fellow of the IEEE, USA. (www.isical.ac.in/~nikhil)
[Editor: Tong Gao]